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Those conditions increase the risk of serious complications from GLP-1-induced constipation

doi: 10.1038/s41416-024-02622-w 329

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Miranti, E

Unlike growth hormone peptides (which work through the pituitary) or GLP-1 peptides (which work through gut and brain receptors), BPC-157 works primarily through a different mechanism: it upregulates growth hormone receptors in tendon cells, stimulates angiogenesis (the formation of new blood vessels), and modulates nitric oxide signaling all of which contribute to accelerated tissue repair and reduced inflammation